Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration
نویسندگان
چکیده
منابع مشابه
HIV associated neurodegeneration requires p53 in neurons and microglia.
HIV infection of the central nervous system leads to HIV-associated dementia (HAD) in a substantial subset of infected individuals. The pathogenesis of neuronal dysfunction in HAD is not well understood, but previous studies have demonstrated evidence for activation of apoptotic pathways. The tumor suppressor transcription factor p53 is an apical mediator of neuronal apoptosis following a varie...
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ژورنال
عنوان ژورنال: Cell
سال: 2018
ISSN: 0092-8674
DOI: 10.1016/j.cell.2018.05.003